Complex of transferrin with ruthenium for medical applications
Abstract
A novel ruthenium-transferrin complex is disclosed which is prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40 C for about 2 hours. The complex is purified by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex. No Drawings
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7242911
- Patent Number(s):
- 4448762
- Application Number:
- PPN: US 6-203194
- Assignee:
- Dept. of Energy, Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 3 Nov 1980
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; GALLIUM 67; UPTAKE; RUTHENIUM; DIAGNOSTIC USES; TRANSFERRIN; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; GALLIUM ISOTOPES; GLOBULINS; GLOBULINS-BETA; INTERMEDIATE MASS NUCLEI; ISOTOPES; METALLOPROTEINS; METALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PLATINUM METALS; PROTEINS; RADIOISOTOPES; TRANSITION ELEMENTS; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Richards, P, Srivastava, S C, and Meinken, G E. Complex of transferrin with ruthenium for medical applications. United States: N. p., 1984.
Web.
Richards, P, Srivastava, S C, & Meinken, G E. Complex of transferrin with ruthenium for medical applications. United States.
Richards, P, Srivastava, S C, and Meinken, G E. Tue .
"Complex of transferrin with ruthenium for medical applications". United States.
@article{osti_7242911,
title = {Complex of transferrin with ruthenium for medical applications},
author = {Richards, P and Srivastava, S C and Meinken, G E},
abstractNote = {A novel ruthenium-transferrin complex is disclosed which is prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40 C for about 2 hours. The complex is purified by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {5}
}
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