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Title: Complex of transferrin with ruthenium for medical applications

Abstract

A novel ruthenium-transferrin complex is disclosed which is prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40 C for about 2 hours. The complex is purified by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex. No Drawings

Inventors:
; ;
Issue Date:
OSTI Identifier:
7242911
Patent Number(s):
4448762 A
Application Number:
PPN: US 6-203194
Assignee:
Dept. of Energy, Washington, DC (United States) PTO; EDB-94-125932
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Patent File Date: 3 Nov 1980
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GALLIUM 67; UPTAKE; RUTHENIUM; DIAGNOSTIC USES; TRANSFERRIN; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; GALLIUM ISOTOPES; GLOBULINS; GLOBULINS-BETA; INTERMEDIATE MASS NUCLEI; ISOTOPES; METALLOPROTEINS; METALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PLATINUM METALS; PROTEINS; RADIOISOTOPES; TRANSITION ELEMENTS; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Richards, P., Srivastava, S.C., and Meinken, G.E. Complex of transferrin with ruthenium for medical applications. United States: N. p., 1984. Web.
Richards, P., Srivastava, S.C., & Meinken, G.E. Complex of transferrin with ruthenium for medical applications. United States.
Richards, P., Srivastava, S.C., and Meinken, G.E. Tue . "Complex of transferrin with ruthenium for medical applications". United States.
@article{osti_7242911,
title = {Complex of transferrin with ruthenium for medical applications},
author = {Richards, P. and Srivastava, S.C. and Meinken, G.E.},
abstractNote = {A novel ruthenium-transferrin complex is disclosed which is prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40 C for about 2 hours. The complex is purified by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {5}
}