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Title: 2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts

Abstract

A process is described for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. The carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of the compounds in methods for boron neutron capture therapy in mammalian tumor cells. No Drawings

Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
7239400
Patent Number(s):
5171849 A
Application Number:
CNN: RO1 CA 41288; BNL 464374; PPN: US 7-688121
Assignee:
Ohio State Univ. Research Foundation, Columbus, OH (United States) PTO; EDB-94-091213
DOE Contract Number:  
FG02-90ER60972
Resource Type:
Patent
Resource Relation:
Patent File Date: 19 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BORON COMPOUNDS; CHEMICAL PREPARATION; NEOPLASMS; NEUTRON CAPTURE THERAPY; URIDINE; THERAPEUTIC USES; AZINES; DISEASES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MEDICINE; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOLOGY; RADIOTHERAPY; RIBOSIDES; SYNTHESIS; THERAPY; URACILS; USES; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Soloway, A.H., Barth, R.F., Anisuzzaman, A.K., Alam, F., and Tjarks, W. 2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts. United States: N. p., 1992. Web.
Soloway, A.H., Barth, R.F., Anisuzzaman, A.K., Alam, F., & Tjarks, W. 2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts. United States.
Soloway, A.H., Barth, R.F., Anisuzzaman, A.K., Alam, F., and Tjarks, W. Tue . "2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts". United States.
@article{osti_7239400,
title = {2[prime] and 3[prime] Carboranyl uridines and their diethyl ether adducts},
author = {Soloway, A.H. and Barth, R.F. and Anisuzzaman, A.K. and Alam, F. and Tjarks, W.},
abstractNote = {A process is described for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. The carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of the compounds in methods for boron neutron capture therapy in mammalian tumor cells. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {12}
}