skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiopharmaceuticals for imaging the heart

Abstract

Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

Inventors:
;
Issue Date:
OSTI Identifier:
7172837
Patent Number(s):
5324502
Application Number:
CNN: R01-CA46909; PPN: US 7-861778
Assignee:
Purdue Research Foundation, West Lafayette, IN (United States)
DOE Contract Number:  
FG02-89ER60868
Resource Type:
Patent
Resource Relation:
Patent File Date: 2 Apr 1992
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GALLIUM 68; UPTAKE; HEART; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Green, M A, and Tsang, B W. Radiopharmaceuticals for imaging the heart. United States: N. p., 1994. Web.
Green, M A, & Tsang, B W. Radiopharmaceuticals for imaging the heart. United States.
Green, M A, and Tsang, B W. Tue . "Radiopharmaceuticals for imaging the heart". United States.
@article{osti_7172837,
title = {Radiopharmaceuticals for imaging the heart},
author = {Green, M A and Tsang, B W},
abstractNote = {Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {6}
}