Electrophoresis-mass spectrometry probe
Abstract
The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface. 8 figs.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7148094
- Patent Number(s):
- 4705616 A
- Application Number:
- PPN: US 6-906847
- Assignee:
- Sepragen Corp., San Leandro, CA (United States) PTO; EDB-94-124745
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 15 Sep 1986
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; MASS SPECTROMETERS; PROBES; MIXTURES; ELECTROPHORESIS; MASS SPECTROSCOPY; DESIGN; EQUIPMENT INTERFACES; REAL TIME SYSTEMS; SEPARATION PROCESSES; DISPERSIONS; MEASURING INSTRUMENTS; SPECTROMETERS; SPECTROSCOPY; 400102* - Chemical & Spectral Procedures; 400105 - Separation Procedures
Citation Formats
Andresen, B.D., and Fought, E.R. Electrophoresis-mass spectrometry probe. United States: N. p., 1987.
Web.
Andresen, B.D., & Fought, E.R. Electrophoresis-mass spectrometry probe. United States.
Andresen, B.D., and Fought, E.R. Tue .
"Electrophoresis-mass spectrometry probe". United States.
@article{osti_7148094,
title = {Electrophoresis-mass spectrometry probe},
author = {Andresen, B.D. and Fought, E.R.},
abstractNote = {The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {11}
}