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Title: Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung

Abstract

A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.

Inventors:
; ; ;
Issue Date:
OSTI Identifier:
7117152
Patent Number(s):
5162231 A
Application Number:
PPN: US 7-539999
Assignee:
PTO; EDB-94-091192
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Resource Relation:
Patent File Date: 15 Jun 1990
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; NEOPLASMS; DIAGNOSIS; RADIOTHERAPY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; COPPER 64; COPPER 67; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COPPER ISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; SYNTHESIS; THERAPY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Cole, D.A., Moody, D.C. III, Ellinwood, L.E., and Klein, M.G. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States: N. p., 1992. Web.
Cole, D.A., Moody, D.C. III, Ellinwood, L.E., & Klein, M.G. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States.
Cole, D.A., Moody, D.C. III, Ellinwood, L.E., and Klein, M.G. Tue . "Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung". United States.
@article{osti_7117152,
title = {Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung},
author = {Cole, D.A. and Moody, D.C. III and Ellinwood, L.E. and Klein, M.G.},
abstractNote = {A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {11}
}