skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Freeze chromatography method and apparatus

Abstract

A freeze chromatography method and apparatus are provided which enable separation of the solutes contained in a sample. The apparatus includes an annular column construction comprising cylindrical inner and outer surfaces defining an annular passage therebetween. One of the surfaces is heated and the other cooled while passing an eluent through the annular passageway so that the eluent in contact with the cooled surface freezes and forms a frozen eluent layer thereon. A mixture of solutes dissolved in eluent is passed through the annular passageway in contact with the frozen layer so that the sample solutes in the mixture will tend to migrate either toward or away the frozen layer. The rate at which the mixture flows through the annular passageway is controlled so that the distribution of the sample solutes approaches that at equilibrium and thus a separation between the sample solutes occurs. 3 figs.

Inventors:
Issue Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
OSTI Identifier:
7045071
Patent Number(s):
-US-A6039130
Assignee:
TIC; EDB-88-178525
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CHROMATOGRAPHY; INVENTIONS; EXTRACTION COLUMNS; FREEZING; DESIGN; ELUTRIATION; MIXTURES; SOLUTES; SURFACES; DISPERSIONS; EXTRACTION APPARATUSES; SEPARATION EQUIPMENT; SEPARATION PROCESSES; 400102* - Chemical & Spectral Procedures

Citation Formats

Scott, C.D. Freeze chromatography method and apparatus. United States: N. p., 1987. Web.
Scott, C.D. Freeze chromatography method and apparatus. United States.
Scott, C.D. Thu . "Freeze chromatography method and apparatus". United States.
@article{osti_7045071,
title = {Freeze chromatography method and apparatus},
author = {Scott, C.D.},
abstractNote = {A freeze chromatography method and apparatus are provided which enable separation of the solutes contained in a sample. The apparatus includes an annular column construction comprising cylindrical inner and outer surfaces defining an annular passage therebetween. One of the surfaces is heated and the other cooled while passing an eluent through the annular passageway so that the eluent in contact with the cooled surface freezes and forms a frozen eluent layer thereon. A mixture of solutes dissolved in eluent is passed through the annular passageway in contact with the frozen layer so that the sample solutes in the mixture will tend to migrate either toward or away the frozen layer. The rate at which the mixture flows through the annular passageway is controlled so that the distribution of the sample solutes approaches that at equilibrium and thus a separation between the sample solutes occurs. 3 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {4}
}