1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof

Title: 1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof

Full Record
Other Related Research

Abstract

The novel labelled compound 1-/sup 11/C-2-deoxy-D-glucose, and a process for its preparation from 2,3:4,5-di-O-isopropylidene-D-arabinitol derivatives of relatively high reactivity are disclosed. 1-/sup 11/C-2-deoxy-D-glucose is useful for measuring regional brain glucose metabolism in vivo.

Inventors:: MacGregor, R.R.; Wolf, A.P.; Shiue, C.Y.; Wan, C.N.

Issue Date:: 1980-02-08

OSTI Identifier:: 6921489

Assignee:: Dept. of Energy TIC; EDB-81-035176

DOE Contract Number:: EY-76-C-02-0016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; CARBON 11; RADIOPHARMACEUTICALS; GLUCOSE; CHEMICAL PREPARATION; BRAIN; IN VIVO; METABOLISM; METABOLITES; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; DRUGS; EVEN-ODD NUCLEI; HEXOSES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; SYNTHESIS 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550501 -- Metabolism-- Tracer Techniques; 551001 -- Physiological Systems-- Tracer Techniques; 400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials

Citation Formats


                    MacGregor, R.R., Wolf, A.P., Shiue, C.Y., and Wan, C.N. 1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof.  United States: N. p., 1980. 
        Web.

Copy to clipboard


                    MacGregor, R.R., Wolf, A.P., Shiue, C.Y., & Wan, C.N. 1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof.  United States.

Copy to clipboard


                    MacGregor, R.R., Wolf, A.P., Shiue, C.Y., and Wan, C.N. Fri .  
        "1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof".  United States.

Copy to clipboard


                    
@article{osti_6921489,

  title        = {1-/sup 11/C-2-deoxy-D-glucose and process for the preparation thereof},

  author       = {MacGregor, R.R. and Wolf, A.P. and Shiue, C.Y. and Wan, C.N.},

  abstractNote = {The novel labelled compound 1-/sup 11/C-2-deoxy-D-glucose, and a process for its preparation from 2,3:4,5-di-O-isopropylidene-D-arabinitol derivatives of relatively high reactivity are disclosed. 1-/sup 11/C-2-deoxy-D-glucose is useful for measuring regional brain glucose metabolism in vivo.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1980},

  month        = {2}

}

Copy to clipboard

Patent:

Search for the full text at the U.S. Patent and Trademark Office

Save / Share:

Export Metadata

Save to My Library

Similar records in DOE Patents and OSTI.GOV collections:

Serial PET studies of human cerebral malignancy with (1-/sup 11/C)putrescine and (1-/sup 11/C)2-deoxy-D-glucose

Journal Article Hiesiger, E.; Fowler, J.S.; Wolf, A.P.; ... - J. Nucl. Med.; (United States)

Serial PET measurements of (1-/sup 11/C)putrescine ((/sup 11/C)PUT) uptake and glucose metabolic rate (GMR) using (1-/sup 11/C)2-deoxy-D-glucose ((/sup 11/C)2DG) were made on eight human subjects with a radiological and, in most cases, pathological diagnosis of primary or metastatic brain tumor. Blood-to-brain influx constants (Ki) were calculated for (/sup 11/C)PUT. Tumor uptake of /sup 11/C after (/sup 11/C)PUT injection was unidirectional peaking at 15 min. The mean +/- s.d. Kis for (/sup 11/C)PUT for tumor and normal brain tissue were 0.78 +/- 0.045 and 0.024 +/- 0.007 ml cc-1 min-1, respectively (average of ratio, 3.11 whereas the ratio of GMR formore »« less
Use of 2-deoxy-D(1-/sup 11/C)glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects

Journal Article Reivich, M.; Alavi, A.; Wolf, A.; ... - J. Cereb. Blood Flow Metab.; (United States)

The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing /sup 14/C-deoxyglucose and in humans employing /sup 18/F-fluorodeoxyglucose. Repeat studies in humans over a relatively brief period of time have not been possible because of the 110-min half-life of /sup 18/F. With the synthesis of /sup 11/C-deoxyglucose it has now become possible to utilize this short-lived (20 min) tracer for the measurement of LCMRgl and to determine its variability within subjects over a 2-h period. The kinetic rate constants for /sup 11/C-deoxyglucose were determined for gray and white matter and foundmore »« less
DOI: 10.1038/jcbfm.1982.32
The unit operations approach applied to the synthesis of (1(-/sup 11/)C)2-deoxy-D-glucose for routine clinical applications

Journal Article Padgett, H.C.; Barrio, J.R.; MacDonald, N.S.; ... - J. Nucl. Med.; (United States)

An approach to the design of remote semiautomated chemical processing systems has been developed and tested in more than 750 production runs. This design stresses the idea of unit operations, which allows maximum flexibility while maintaining the highest possible standards regarding safety, reliability, efficiency, and practicality. Application of this approach has resulted in the development of a simple and reliable remote semiautomated synthesis system for the routine production of (1(-/sup 11/)C)2-deoxy-D-glucose. Use of this system results in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min, with radiochemical purity of greatermore »« less
Synthesis of 2-deoxy-D-(1-/sup 11/C)glucose for regional metabolic studies: concise communication

Journal Article MacGregor, R.R.; Fowler, J.S.; Wolf, A.P.; ... - J. Nucl. Med.; (United States)

A synthesis of 2-deoxy-D-(1-/sup 11/C)glucose from H/sup 11/CN has been developed. This compound is obtained in a radiochemical yield of 30 to 40% with a synthesis time of 45 min.
Process for the production of /sup 18/F-2-deoxy-2-fluoro-D-glucose

Patent Elmaleh, D.R.; Levy, S.; Shiue, C.Y.; ...

A method of preparing the radiopharmaceutical 2-deoxy-2-(/sup 18/F) fluoro-D-glucose (/sup 18/FDG) in high yield and in highly purified form is described. (ACR)

Similar Records