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Title: Method for detection of long-lived radioisotopes in small biochemical samples

Disclosed is a method for detection of long-lived radioisotopes in small biochemical samples, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biologist host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figs.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
6868971
Assignee:
Univ. of California, Oakland, CA (United States) PTO; EDB-94-170589
Patent Number(s):
US 5366721; A
Application Number:
PPN: US 7-699385
Contract Number:
W-7405-ENG-48
Resource Relation:
Patent File Date: 26 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIOLOGICAL MATERIALS; RADIOCHEMICAL ANALYSIS; MEASURING METHODS; RADIATION DOSES; SAMPLE PREPARATION; CHEMICAL ANALYSIS; DOSES; MATERIALS; QUANTITATIVE CHEMICAL ANALYSIS 560152* -- Radiation Effects on Animals-- Animals; 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells