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Title: Mutation assays involving blood cells that metabolize toxic substances

Abstract

The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.

Inventors:
;
Issue Date:
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
678583
Patent Number(s):
5935829
Application Number:
PAN: 7-817,971
Assignee:
Massachusetts Inst. of Tech., Cambridge, MA (United States)
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 10 Aug 1999
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; BLOOD CELLS; XENOBIOTICS; MUTAGEN SCREENING; MAN; ENZYME ACTIVITY; METABOLISM

Citation Formats

Crespi, C L, and Thilly, W G. Mutation assays involving blood cells that metabolize toxic substances. United States: N. p., 1999. Web.
Crespi, C L, & Thilly, W G. Mutation assays involving blood cells that metabolize toxic substances. United States.
Crespi, C L, and Thilly, W G. Tue . "Mutation assays involving blood cells that metabolize toxic substances". United States.
@article{osti_678583,
title = {Mutation assays involving blood cells that metabolize toxic substances},
author = {Crespi, C L and Thilly, W G},
abstractNote = {The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {8}
}