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Title: Electro-osmotically driven liquid delivery method and apparatus

Abstract

Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
678557
Patent Number(s):
5942093
Application Number:
PAN: 8-878,470
Assignee:
Sandia Corp., Livermore, CA (United States)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 24 Aug 1999
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING NOT INCLUDED IN OTHER CATEGORIES; FLOW REGULATORS; LIQUIDS; DESIGN; FLOW RATE; CHEMICAL COMPOSITION; PROCESS CONTROL; MIXTURES; ELECTRIC POTENTIAL

Citation Formats

Rakestraw, D J, Anex, D S, Yan, C, Dadoo, R, and Zare, R N. Electro-osmotically driven liquid delivery method and apparatus. United States: N. p., 1999. Web.
Rakestraw, D J, Anex, D S, Yan, C, Dadoo, R, & Zare, R N. Electro-osmotically driven liquid delivery method and apparatus. United States.
Rakestraw, D J, Anex, D S, Yan, C, Dadoo, R, and Zare, R N. Tue . "Electro-osmotically driven liquid delivery method and apparatus". United States.
@article{osti_678557,
title = {Electro-osmotically driven liquid delivery method and apparatus},
author = {Rakestraw, D J and Anex, D S and Yan, C and Dadoo, R and Zare, R N},
abstractNote = {Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {8}
}