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Title: Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Abstract

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
675822
Patent Number(s):
5832931
Application Number:
PAN: 8-741,370
Assignee:
Photogen, Inc., Oak Ridge, TN (United States)
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 10 Nov 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DIAGNOSIS; IMAGE PROCESSING; PLANT TISSUES; ANIMAL TISSUES; PHOTOCHEMICAL REACTIONS

Citation Formats

Wachter, E A, Fisher, W G, and Dees, H C. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States: N. p., 1998. Web.
Wachter, E A, Fisher, W G, & Dees, H C. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States.
Wachter, E A, Fisher, W G, and Dees, H C. Tue . "Method for improved selectivity in photo-activation and detection of molecular diagnostic agents". United States.
@article{osti_675822,
title = {Method for improved selectivity in photo-activation and detection of molecular diagnostic agents},
author = {Wachter, E A and Fisher, W G and Dees, H C},
abstractNote = {A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {11}
}