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Title: Diagnostic method employing MSH2 protein

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Eleanor Roosevelt Institute
Sponsoring Org.:
USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
OSTI Identifier:
675821
Patent Number(s):
5,837,443
Application Number:
PAN: 8-457,374; CNN: Grant DOE/ERN/F139;Grant NIH CA47527;Grant NIH CA09320;Grant NIH GM26449;Grant NIH CA09243;Grant NIH CA41183;Grant NIH CA42705;Grant NIH CA57435;Grant NIH CA35494
Assignee:
Johns Hopkins Univ., Baltimore, MD (United States) PTO; SCA: 550200; 550900; 550600; PA: EDB-99:003697; SN: 98002027947
DOE Contract Number:  
FG02-91ER61139
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 17 Nov 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; DNA SEQUENCING; DNA-CLONING; NEOPLASMS; RECTUM; LARGE INTESTINE; MAN; GENE MUTATIONS; HEREDITARY DISEASES; DIAGNOSIS

Citation Formats

Chapelle, A. de la, Vogelstein, B., and Kinzler, K.W. Diagnostic method employing MSH2 protein. United States: N. p., 1998. Web.
Chapelle, A. de la, Vogelstein, B., & Kinzler, K.W. Diagnostic method employing MSH2 protein. United States.
Chapelle, A. de la, Vogelstein, B., and Kinzler, K.W. Tue . "Diagnostic method employing MSH2 protein". United States.
@article{osti_675821,
title = {Diagnostic method employing MSH2 protein},
author = {Chapelle, A. de la and Vogelstein, B. and Kinzler, K.W.},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {11}
}