Prolonged cold storage of red blood cells by oxygen removal and additive usage
Abstract
Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials. 8 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 672690
- Patent Number(s):
- 5789151
- Application Number:
- PAN: 8-857,474
- Assignee:
- Univ. of California, Los Alamos, NM (United States)
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 4 Aug 1998
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; ERYTHROCYTES; STORAGE LIFE; TRANSFUSIONS; COLD STORAGE; ATP; OXYGEN
Citation Formats
Bitensky, M W, and Yoshida, Tatsuro. Prolonged cold storage of red blood cells by oxygen removal and additive usage. United States: N. p., 1998.
Web.
Bitensky, M W, & Yoshida, Tatsuro. Prolonged cold storage of red blood cells by oxygen removal and additive usage. United States.
Bitensky, M W, and Yoshida, Tatsuro. Tue .
"Prolonged cold storage of red blood cells by oxygen removal and additive usage". United States.
@article{osti_672690,
title = {Prolonged cold storage of red blood cells by oxygen removal and additive usage},
author = {Bitensky, M W and Yoshida, Tatsuro},
abstractNote = {Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {8}
}