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Title: Optical reaction cell and light source for [18F] fluoride radiotracer synthesis

Abstract

An apparatus is disclosed for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-[{sup 18}F]fluoro-2-deoxy-Dglucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of [{sup 18}F]-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose in higher yields than previously possible. 4 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Associated Universities Inc
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
672679
Patent Number(s):
5808020
Application Number:
PAN: 8-694,398; TRN: 99:001109
Assignee:
Associated Universities, Inc., Washington, DC (United States)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 15 Sep 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; FLUORINE 18

Citation Formats

Ferrieri, R A, Schlyer, D, and Becker, R J. Optical reaction cell and light source for [18F] fluoride radiotracer synthesis. United States: N. p., 1998. Web.
Ferrieri, R A, Schlyer, D, & Becker, R J. Optical reaction cell and light source for [18F] fluoride radiotracer synthesis. United States.
Ferrieri, R A, Schlyer, D, and Becker, R J. Tue . "Optical reaction cell and light source for [18F] fluoride radiotracer synthesis". United States.
@article{osti_672679,
title = {Optical reaction cell and light source for [18F] fluoride radiotracer synthesis},
author = {Ferrieri, R A and Schlyer, D and Becker, R J},
abstractNote = {An apparatus is disclosed for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-[{sup 18}F]fluoro-2-deoxy-Dglucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of [{sup 18}F]-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose in higher yields than previously possible. 4 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {9}
}