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Title: Rigid bifunctional chelating agents

Abstract

Bicyclo[2.2.2] octane-2,3 diamine-N,N,N`,N`-tetraacetic acids (BODTA) and bicyclo[2.2.1] heptane-2,3 diamine-N,N,N`,N`-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

Inventors:
; ;
Issue Date:
Research Org.:
Associated Universities Inc
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
672562
Patent Number(s):
5783169
Application Number:
PAN: 8-506,889; TRN: 99:001057
Assignee:
Brookhaven Science Associates LLC, Upton, NY (United States)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 21 Jul 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CHELATING AGENTS; DIAGNOSTIC USES; THERAPEUTIC USES; NEOPLASMS; RADIOIMMUNOTHERAPY; UPTAKE

Citation Formats

Sweet, M P, Mease, R C, and Srivastava, S C. Rigid bifunctional chelating agents. United States: N. p., 1998. Web.
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Sweet, M P, Mease, R C, & Srivastava, S C. Rigid bifunctional chelating agents. United States.
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Sweet, M P, Mease, R C, and Srivastava, S C. Tue . "Rigid bifunctional chelating agents". United States.
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@article{osti_672562,
title = {Rigid bifunctional chelating agents},
author = {Sweet, M P and Mease, R C and Srivastava, S C},
abstractNote = {Bicyclo[2.2.2] octane-2,3 diamine-N,N,N`,N`-tetraacetic acids (BODTA) and bicyclo[2.2.1] heptane-2,3 diamine-N,N,N`,N`-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 21 00:00:00 EDT 1998},
month = {Tue Jul 21 00:00:00 EDT 1998}
}
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