Method for identifying and quantifying nucleic acid sequence aberrations
Abstract
A method is disclosed for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe. 11 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 672561
- Patent Number(s):
- 5783387
- Application Number:
- PAN: 8-384,497
- Assignee:
- Univ. of California, Oakland, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 21 Jul 1998
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; AMINO ACID SEQUENCE; NUCLEIC ACIDS; NUCLEIC ACID HYBRIDIZATION; BIOLOGICAL MARKERS
Citation Formats
Lucas, J N, Straume, T, and Bogen, K T. Method for identifying and quantifying nucleic acid sequence aberrations. United States: N. p., 1998.
Web.
Lucas, J N, Straume, T, & Bogen, K T. Method for identifying and quantifying nucleic acid sequence aberrations. United States.
Lucas, J N, Straume, T, and Bogen, K T. Tue .
"Method for identifying and quantifying nucleic acid sequence aberrations". United States.
@article{osti_672561,
title = {Method for identifying and quantifying nucleic acid sequence aberrations},
author = {Lucas, J N and Straume, T and Bogen, K T},
abstractNote = {A method is disclosed for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe. 11 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 21 00:00:00 EDT 1998},
month = {Tue Jul 21 00:00:00 EDT 1998}
}