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Title: Method for identifying and quantifying nucleic acid sequence aberrations

Abstract

A method is disclosed for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe. 11 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
672561
Patent Number(s):
5,783,387
Application Number:
PAN: 8-384,497
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 21 Jul 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; AMINO ACID SEQUENCE; NUCLEIC ACIDS; NUCLEIC ACID HYBRIDIZATION; BIOLOGICAL MARKERS

Citation Formats

Lucas, J N, Straume, T, and Bogen, K T. Method for identifying and quantifying nucleic acid sequence aberrations. United States: N. p., 1998. Web.
Lucas, J N, Straume, T, & Bogen, K T. Method for identifying and quantifying nucleic acid sequence aberrations. United States.
Lucas, J N, Straume, T, and Bogen, K T. Tue . "Method for identifying and quantifying nucleic acid sequence aberrations". United States.
@article{osti_672561,
title = {Method for identifying and quantifying nucleic acid sequence aberrations},
author = {Lucas, J N and Straume, T and Bogen, K T},
abstractNote = {A method is disclosed for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe. 11 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {7}
}