skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: (/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography

Abstract

This invention involves a new strategy for imaging the activity of the enzyme monoamine oxidase in the living body by using /sup 11/C-labeled enzyme inhibitors which bind irreversibly to an enzyme as a result of catalysis. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography. 2 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
OSTI Identifier:
6701426
Application Number:
ON: DE87007235
Assignee:
Dept. of Energy
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; BRAIN; POSITRON COMPUTED TOMOGRAPHY; SYMPATHOMIMETICS; LABELLING; AMINE OXIDASES; BABOONS; BLOOD; CARBON 11; CHEMICAL PREPARATION; ENZYME INHIBITORS; HEART; LIVER; LUNGS; MICE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBON ISOTOPES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISTRIBUTION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; ENZYMES; EVEN-ODD NUCLEI; GLANDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; MONKEYS; NERVOUS SYSTEM; NUCLEI; ORGANS; OXIDOREDUCTASES; PRIMATES; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SYNTHESIS; TOMOGRAPHY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials

Citation Formats

Fowler, J S, MacGregor, R R, and Wolf, A P. (/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography. United States: N. p., 1986. Web.
Fowler, J S, MacGregor, R R, & Wolf, A P. (/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography. United States.
Fowler, J S, MacGregor, R R, and Wolf, A P. Thu . "(/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography". United States.
@article{osti_6701426,
title = {(/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography},
author = {Fowler, J S and MacGregor, R R and Wolf, A P},
abstractNote = {This invention involves a new strategy for imaging the activity of the enzyme monoamine oxidase in the living body by using /sup 11/C-labeled enzyme inhibitors which bind irreversibly to an enzyme as a result of catalysis. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography. 2 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {4}
}