Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/
Abstract
A stable boronated (/sup 10/B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/, at a dose of about 200 ..mu..g /sup 10/B per gm body weight. The infusion is preformed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 ..mu..g /sup 10/B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of /sup 10/B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of /sup 10/B in the tumor. 1 tab.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- OSTI Identifier:
- 6698230
- Application Number:
- ON: DE87007218
- Assignee:
- Dept. of Energy
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; BORON HYDRIDES; THERAPEUTIC USES; TISSUE DISTRIBUTION; CEREBRUM; NEOPLASMS; GLIOMAS; NEUTRON THERAPY; BORON 10; MICE; STRUCTURE-ACTIVITY RELATIONSHIPS; THIOLS; ANIMALS; BODY; BORON COMPOUNDS; BORON ISOTOPES; BRAIN; CENTRAL NERVOUS SYSTEM; DISEASES; DISTRIBUTION; HYDRIDES; HYDROGEN COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOLOGY; RADIOTHERAPY; RODENTS; STABLE ISOTOPES; THERAPY; USES; VERTEBRATES; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
Citation Formats
Slatkin, D N, Micca, P L, and Fairchild, R G. Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/. United States: N. p., 1986.
Web.
Slatkin, D N, Micca, P L, & Fairchild, R G. Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/. United States.
Slatkin, D N, Micca, P L, and Fairchild, R G. Tue .
"Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/". United States.
@article{osti_6698230,
title = {Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/},
author = {Slatkin, D N and Micca, P L and Fairchild, R G},
abstractNote = {A stable boronated (/sup 10/B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/, at a dose of about 200 ..mu..g /sup 10/B per gm body weight. The infusion is preformed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 ..mu..g /sup 10/B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of /sup 10/B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of /sup 10/B in the tumor. 1 tab.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {3}
}