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Title: Process for the separation and purification of yttrium-90 for medical applications

An extraction chromatographic method for the preparation of [sup 90]Y of high chemical and radiochemical purity is disclosed. After an initial purification of a [sup 90]Sr stock solution and a suitable period of [sup 90]Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the [sup 90]Sr content of the mixture by a factor of about 10[sup 3]. The [sup 90]Y remaining is freed from any residual [sup 90]Sr, from its [sup 90]Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium. 5 figures.
Inventors:
;
Issue Date:
OSTI Identifier:
6649133
Assignee:
Dept. of Energy, Washington, DC (United States) PTO; EDB-95-031465
Patent Number(s):
US 5368736; A
Application Number:
PPN: US 8-095555
Contract Number:
W-31109-ENG-38
Resource Relation:
Patent File Date: 26 Jul 1993
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; YTTRIUM 90; CHROMATOGRAPHY; PURIFICATION; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS; YTTRIUM ISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 400105 -- Separation Procedures