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Title: Process for the separation and purification of yttrium-90 for medical applications

Abstract

An extraction chromatographic method for the preparation of [sup 90]Y of high chemical and radiochemical purity is disclosed. After an initial purification of a [sup 90]Sr stock solution and a suitable period of [sup 90]Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the [sup 90]Sr content of the mixture by a factor of about 10[sup 3]. The [sup 90]Y remaining is freed from any residual [sup 90]Sr, from its [sup 90]Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium. 5 figures.

Inventors:
;
Issue Date:
OSTI Identifier:
6649133
Patent Number(s):
5368736 A
Application Number:
PPN: US 8-095555
Assignee:
Dept. of Energy, Washington, DC (United States)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 26 Jul 1993
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; YTTRIUM 90; CHROMATOGRAPHY; PURIFICATION; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS; YTTRIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400105 - Separation Procedures

Citation Formats

Horwitz, P E, and Dietz, M L. Process for the separation and purification of yttrium-90 for medical applications. United States: N. p., 1994. Web.
Horwitz, P E, & Dietz, M L. Process for the separation and purification of yttrium-90 for medical applications. United States.
Horwitz, P E, and Dietz, M L. Tue . "Process for the separation and purification of yttrium-90 for medical applications". United States.
@article{osti_6649133,
title = {Process for the separation and purification of yttrium-90 for medical applications},
author = {Horwitz, P E and Dietz, M L},
abstractNote = {An extraction chromatographic method for the preparation of [sup 90]Y of high chemical and radiochemical purity is disclosed. After an initial purification of a [sup 90]Sr stock solution and a suitable period of [sup 90]Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the [sup 90]Sr content of the mixture by a factor of about 10[sup 3]. The [sup 90]Y remaining is freed from any residual [sup 90]Sr, from its [sup 90]Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium. 5 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {11}
}