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Title: Method of measurement in biological systems

Abstract

Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.

Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
6610179
Patent Number(s):
5376355 A
Application Number:
PPN: US 7-693239
Assignee:
University of California, Oakland, CA (United States) PTO; EDB-95-031442
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Patent File Date: 26 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; COUNTING TECHNIQUES; BIOLOGICAL MATERIALS; NUCLEAR MEDICINE; RADIATION DOSES; DOSES; DRUGS; LABELLED COMPOUNDS; MATERIALS; MEDICINE 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., and Davis, J.C. Method of measurement in biological systems. United States: N. p., 1994. Web.
Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., & Davis, J.C. Method of measurement in biological systems. United States.
Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., and Davis, J.C. Tue . "Method of measurement in biological systems". United States.
@article{osti_6610179,
title = {Method of measurement in biological systems},
author = {Turteltaub, K.W. and Vogel, J.S. and Felton, J.S. and Gledhill, B.L. and Davis, J.C.},
abstractNote = {Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {12}
}