Method of measurement in biological systems
Abstract
Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 6610179
- Patent Number(s):
- 5376355 A
- Application Number:
- PPN: US 7-693239
- Assignee:
- University of California, Oakland, CA (United States) PTO; EDB-95-031442
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 26 Apr 1991
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; COUNTING TECHNIQUES; BIOLOGICAL MATERIALS; NUCLEAR MEDICINE; RADIATION DOSES; DOSES; DRUGS; LABELLED COMPOUNDS; MATERIALS; MEDICINE 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
Citation Formats
Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., and Davis, J.C. Method of measurement in biological systems. United States: N. p., 1994.
Web.
Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., & Davis, J.C. Method of measurement in biological systems. United States.
Turteltaub, K.W., Vogel, J.S., Felton, J.S., Gledhill, B.L., and Davis, J.C. Tue .
"Method of measurement in biological systems". United States.
@article{osti_6610179,
title = {Method of measurement in biological systems},
author = {Turteltaub, K.W. and Vogel, J.S. and Felton, J.S. and Gledhill, B.L. and Davis, J.C.},
abstractNote = {Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {12}
}