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Title: 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group

Abstract

The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.

Inventors:
; ;
Issue Date:
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
6478659
Patent Number(s):
5908926
Application Number:
PPN: US 8-406327
Assignee:
Duke Univ., Durham, NC (United States)
DOE Contract Number:  
FG05-92ER61388
Resource Type:
Patent
Resource Relation:
Patent File Date: 16 Mar 1995
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHEMICAL ANALYSIS; CHEMICAL PREPARATION; MUTATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS; 550200* - Biochemistry

Citation Formats

Pirrung, M C, Shuey, S W, and Bradley, J C. 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group. United States: N. p., 1999. Web.
Pirrung, M C, Shuey, S W, & Bradley, J C. 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group. United States.
Pirrung, M C, Shuey, S W, and Bradley, J C. Tue . "5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group". United States.
@article{osti_6478659,
title = {5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group},
author = {Pirrung, M C and Shuey, S W and Bradley, J C},
abstractNote = {The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {6}
}