5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group
Abstract
The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
- Inventors:
- Issue Date:
- Sponsoring Org.:
- USDOE; USDOE, Washington, DC (United States)
- OSTI Identifier:
- 6478659
- Patent Number(s):
- 5908926
- Application Number:
- PPN: US 8-406327
- Assignee:
- Duke Univ., Durham, NC (United States)
- DOE Contract Number:
- FG05-92ER61388
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 16 Mar 1995
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; CHEMICAL ANALYSIS; CHEMICAL PREPARATION; MUTATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS; 550200* - Biochemistry
Citation Formats
Pirrung, M C, Shuey, S W, and Bradley, J C. 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group. United States: N. p., 1999.
Web.
Pirrung, M C, Shuey, S W, & Bradley, J C. 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group. United States.
Pirrung, M C, Shuey, S W, and Bradley, J C. Tue .
"5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group". United States.
@article{osti_6478659,
title = {5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group},
author = {Pirrung, M C and Shuey, S W and Bradley, J C},
abstractNote = {The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {6}
}
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