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Title: Bismuth generator method

Abstract

A method is described for separating {sup 213}Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon {sup 213}Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as {sup 225}Ra, {sup 225}Ac, and {sup 221}Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The {sup 213}Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the {sup 213}Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the {sup 213}Bi. A preferred stripping solution for purification of {sup 213}Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc receives the {sup 213}Bimore » as it is being released from the anion exchange resin. 10 figs.« less

Inventors:
;
Issue Date:
Research Org.:
Battelle Memorial Institute, Columbus, OH (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
645951
Patent Number(s):
5749042
Application Number:
PAN: 8-789,973; TRN: 98:007954
Assignee:
Battelle Memorial Inst., Richland, WA (United States)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 5 May 1998
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; BISMUTH 213; ION EXCHANGE; BISMUTH CHLORIDES; ION EXCHANGE MATERIALS; DESORPTION; RADIOPHARMACEUTICALS

Citation Formats

Bray, L A, and DesChane, J R. Bismuth generator method. United States: N. p., 1998. Web.
Bray, L A, & DesChane, J R. Bismuth generator method. United States.
Bray, L A, and DesChane, J R. Tue . "Bismuth generator method". United States.
@article{osti_645951,
title = {Bismuth generator method},
author = {Bray, L A and DesChane, J R},
abstractNote = {A method is described for separating {sup 213}Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon {sup 213}Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as {sup 225}Ra, {sup 225}Ac, and {sup 221}Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The {sup 213}Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the {sup 213}Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the {sup 213}Bi. A preferred stripping solution for purification of {sup 213}Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc receives the {sup 213}Bi as it is being released from the anion exchange resin. 10 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {5}
}