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Title: Identification of cell density signal molecule

Abstract

Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use. 2 figs.

Inventors:
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
644377
Patent Number(s):
5741895
Application Number:
PAN: 8-445,367
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 21 Apr 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CELL CULTURES; TENDONS; CELL PROLIFERATION; FIBROBLASTS; COLLAGEN; DIAGNOSIS; THERAPY; DISEASES; PROTEINS; BIOSYNTHESIS

Citation Formats

Schwarz, R I. Identification of cell density signal molecule. United States: N. p., 1998. Web.
Schwarz, R I. Identification of cell density signal molecule. United States.
Schwarz, R I. Tue . "Identification of cell density signal molecule". United States.
@article{osti_644377,
title = {Identification of cell density signal molecule},
author = {Schwarz, R I},
abstractNote = {Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use. 2 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {4}
}