Global to push GA events into
skip to main content

Title: Method for selective recovery of PET-usable quantities of [{sup 18}F] fluoride and [{sup 13}N] nitrate/nitrite from a single irradiation of low-enriched [{sup 18}O] water

A process for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} for radiotracer synthesis is disclosed. The process includes producing [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}}and [{sup 18}F]F{sup {minus}} simultaneously by exposing a low-enriched (20%-30%) [{sup 18}O]H{sub 2}O target to proton irradiation, sequentially isolating the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} from the [{sup 18}O]H{sub 2}O target, and reducing the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} to [{sup 13}N]NH{sub 3}. The [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [{sup 18}O]H{sub 2}O, and sequential elution of [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} from a single irradiation of a single low-enriched [{sup 18}O]H{sub 2}O target. 2 figs.
Inventors:
; ;
Issue Date:
OSTI Identifier:
63429
Assignee:
Associated Universities, Inc., Washington, DC (United States) PTO; SCA: 400703; PA: EDB-95:091993; SN: 95001401172
Patent Number(s):
US 5,425,063/A/
Application Number:
PAN: 8-042,741
Contract Number:
AC02-76CH00016
Resource Relation:
Other Information: PBD: 13 Jun 1995
Research Org:
Associated Universities Inc
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; FLUORINE 18; ISOTOPE PRODUCTION; NITROGEN 13; OXYGEN 18 TARGET; PROTON REACTIONS; FLUORIDES; NITRATES; NITRITES; WATER; REDUCTION; TRACER TECHNIQUES; ION EXCHANGE; AMINES; POSITRON COMPUTED TOMOGRAPHY

Similar records in DOepatents and OSTI.GOV collections: