Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
Abstract
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.
- Inventors:
- Issue Date:
- Sponsoring Org.:
- USDOE; USDOE, Washington, DC (United States)
- OSTI Identifier:
- 6298489
- Patent Number(s):
- 5919797
- Application Number:
- PPN: US 8-840651
- Assignee:
- Emory Univ., Atlanta, GA (United States)
- DOE Contract Number:
- FG05-93ER61737
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 24 Apr 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; AFFINITY; LABELLING; MEMBRANE TRANSPORT; PIPERIDINES; RECEPTORS; SEROTONIN; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZINES; AZOLES; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; MEMBRANE PROTEINS; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; PYRIDINES; PYRROLES; RADIOPROTECTIVE SUBSTANCES; SYMPATHOMIMETICS; TRYPTAMINES; 550200* - Biochemistry
Citation Formats
Goodman, M M, and Faraj, B. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States: N. p., 1999.
Web.
Goodman, M M, & Faraj, B. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States.
Goodman, M M, and Faraj, B. Tue .
"Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites". United States.
@article{osti_6298489,
title = {Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites},
author = {Goodman, M M and Faraj, B},
abstractNote = {Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {7}
}
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