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Title: Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

Abstract

Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.

Inventors:
;
Issue Date:
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
6298489
Patent Number(s):
5919797 A
Application Number:
PPN: US 8-840651
Assignee:
Emory Univ., Atlanta, GA (United States) PTO; EDB-99-086040
DOE Contract Number:  
FG05-93ER61737
Resource Type:
Patent
Resource Relation:
Patent File Date: 24 Apr 1997
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; AFFINITY; LABELLING; MEMBRANE TRANSPORT; PIPERIDINES; RECEPTORS; SEROTONIN; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZINES; AZOLES; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; MEMBRANE PROTEINS; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; PYRIDINES; PYRROLES; RADIOPROTECTIVE SUBSTANCES; SYMPATHOMIMETICS; TRYPTAMINES; 550200* - Biochemistry

Citation Formats

Goodman, M.M., and Faraj, B. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States: N. p., 1999. Web.
Goodman, M.M., & Faraj, B. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States.
Goodman, M.M., and Faraj, B. Tue . "Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites". United States.
@article{osti_6298489,
title = {Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites},
author = {Goodman, M.M. and Faraj, B.},
abstractNote = {Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {7}
}