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Title: Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Abstract

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.

Inventors:
;
Issue Date:
Research Org.:
The Johns Hopkins University (Baltimore, MD)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH); USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
OSTI Identifier:
6281399
Patent Number(s):
5912339
Application Number:
PPN: US 8-342005
Assignee:
The Johns Hopkins University (Baltimore, MD)
DOE Contract Number:  
FG02-88ER60636
Resource Type:
Patent
Resource Relation:
Patent File Date: 16 Nov 1994
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHEMICAL COMPOSITION; CLEAVAGE; CROSS-LINKING; NUCLEIC ACIDS; NUCLEOSIDES; PHOSPHONATES; CHEMICAL REACTIONS; MICROSTRUCTURE; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; POLYMERIZATION; RIBOSIDES; 550200* - Biochemistry

Citation Formats

Miller, P S, and Ts'o, P O.P. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States: N. p., 1999. Web.
Miller, P S, & Ts'o, P O.P. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States.
Miller, P S, and Ts'o, P O.P. Tue . "Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids". United States.
@article{osti_6281399,
title = {Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids},
author = {Miller, P S and Ts'o, P O.P.},
abstractNote = {A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {6}
}