Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
Abstract
A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.
- Inventors:
- Issue Date:
- Research Org.:
- The Johns Hopkins University (Baltimore, MD)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH); USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- OSTI Identifier:
- 6281399
- Patent Number(s):
- 5912339
- Application Number:
- PPN: US 8-342005
- Assignee:
- The Johns Hopkins University (Baltimore, MD)
- DOE Contract Number:
- FG02-88ER60636
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 16 Nov 1994
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; CHEMICAL COMPOSITION; CLEAVAGE; CROSS-LINKING; NUCLEIC ACIDS; NUCLEOSIDES; PHOSPHONATES; CHEMICAL REACTIONS; MICROSTRUCTURE; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; POLYMERIZATION; RIBOSIDES; 550200* - Biochemistry
Citation Formats
Miller, P S, and Ts'o, P O.P. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States: N. p., 1999.
Web.
Miller, P S, & Ts'o, P O.P. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States.
Miller, P S, and Ts'o, P O.P. Tue .
"Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids". United States.
@article{osti_6281399,
title = {Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids},
author = {Miller, P S and Ts'o, P O.P.},
abstractNote = {A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {6}
}