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Title: Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters

Abstract

A process is disclosed for preparing an acid addition salt of delta-aminolevulinic acid comprising. The process involves dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing the alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

Inventors:
Issue Date:
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
6281392
Patent Number(s):
5907058
Application Number:
PPN: US 9-124489
Assignee:
Midwest Research Inst., Kansas City, MO (United States)
DOE Contract Number:  
AC36-83CH10093
Resource Type:
Patent
Resource Relation:
Patent File Date: 29 Jul 1998
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; AMINOLEVULINIC ACID; CHEMICAL PREPARATION; INORGANIC ACIDS; SALTS; AMINO ACIDS; CARBOXYLIC ACIDS; HYDROGEN COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS; 550200* - Biochemistry

Citation Formats

Moens, L. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States: N. p., 1999. Web.
Moens, L. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States.
Moens, L. Tue . "Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters". United States.
@article{osti_6281392,
title = {Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters},
author = {Moens, L},
abstractNote = {A process is disclosed for preparing an acid addition salt of delta-aminolevulinic acid comprising. The process involves dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing the alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {5}
}