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Title: Method of measurement in biological systems

Abstract

A method is disclosed of quantifying molecules in biological substances, comprising: selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere; preparing a long-lived radioisotope labeled reactive chemical specie; administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system; allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host; isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources; converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation; and measuring the radioisotope concentration in the material by means of direct isotopic counting.

Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
6279626
Patent Number(s):
5209919
Application Number:
PPN: US 7-693248
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Patent File Date: 26 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; TRACER TECHNIQUES; DESIGN; XENOBIOTICS; MEASURING METHODS; BIOLOGICAL MATERIALS; METABOLISM; MOLECULES; RADIOISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; 560300* - Chemicals Metabolism & Toxicology; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Turteltaub, K W, Vogel, J S, Felton, J S, Gledhill, B.L.: Davis, J.C., and Stanker, L H. Method of measurement in biological systems. United States: N. p., 1993. Web.
Turteltaub, K W, Vogel, J S, Felton, J S, Gledhill, B.L.: Davis, J.C., & Stanker, L H. Method of measurement in biological systems. United States.
Turteltaub, K W, Vogel, J S, Felton, J S, Gledhill, B.L.: Davis, J.C., and Stanker, L H. Tue . "Method of measurement in biological systems". United States.
@article{osti_6279626,
title = {Method of measurement in biological systems},
author = {Turteltaub, K W and Vogel, J S and Felton, J S and Gledhill, B.L.: Davis, J.C. and Stanker, L H},
abstractNote = {A method is disclosed of quantifying molecules in biological substances, comprising: selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere; preparing a long-lived radioisotope labeled reactive chemical specie; administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system; allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host; isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources; converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation; and measuring the radioisotope concentration in the material by means of direct isotopic counting.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {5}
}