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Title: Regioselective chemical modification of monoclonal antibodies

Abstract

A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of Pittsburgh, PA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
6247802
Patent Number(s):
5208008
Application Number:
07/613,127
Assignee:
University of Pittsburgh (Pittsburgh, PA)
DOE Contract Number:  
FG02-89ER60869
Resource Type:
Patent
Resource Relation:
Patent File Date: 14 Nov 1990
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; IMMUNOGLOBULINS; BIOCHEMISTRY; MONOCLONAL ANTIBODIES; IMMUNITY; MODIFICATIONS; ANTIBODIES; CHEMISTRY; GLOBULINS; ORGANIC COMPOUNDS; PROTEINS; 550200* - Biochemistry

Citation Formats

Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, and Bloomer, William. Regioselective chemical modification of monoclonal antibodies. United States: N. p., 1993. Web.
Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, & Bloomer, William. Regioselective chemical modification of monoclonal antibodies. United States.
Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, and Bloomer, William. Tue . "Regioselective chemical modification of monoclonal antibodies". United States.
@article{osti_6247802,
title = {Regioselective chemical modification of monoclonal antibodies},
author = {Ranadive, Girish and Rozenzweig, Howard S. and Epperly, Michael and Bloomer, William},
abstractNote = {A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {5}
}