Regioselective chemical modification of monoclonal antibodies
Abstract
A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Pittsburgh, PA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 6247802
- Patent Number(s):
- 5208008
- Application Number:
- 07/613,127
- Assignee:
- University of Pittsburgh (Pittsburgh, PA)
- DOE Contract Number:
- FG02-89ER60869
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 14 Nov 1990
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; IMMUNOGLOBULINS; BIOCHEMISTRY; MONOCLONAL ANTIBODIES; IMMUNITY; MODIFICATIONS; ANTIBODIES; CHEMISTRY; GLOBULINS; ORGANIC COMPOUNDS; PROTEINS; 550200* - Biochemistry
Citation Formats
Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, and Bloomer, William. Regioselective chemical modification of monoclonal antibodies. United States: N. p., 1993.
Web.
Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, & Bloomer, William. Regioselective chemical modification of monoclonal antibodies. United States.
Ranadive, Girish, Rozenzweig, Howard S., Epperly, Michael, and Bloomer, William. Tue .
"Regioselective chemical modification of monoclonal antibodies". United States.
@article{osti_6247802,
title = {Regioselective chemical modification of monoclonal antibodies},
author = {Ranadive, Girish and Rozenzweig, Howard S. and Epperly, Michael and Bloomer, William},
abstractNote = {A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {5}
}