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Title: Electromagnetic field triggered drug and chemical delivery via liposomes

Abstract

The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

Inventors:
Issue Date:
OSTI Identifier:
6245719
Patent Number(s):
5190761
Application Number:
PPN: US 7-537191
Assignee:
IMS; EDB-93-123395
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Patent File Date: 12 Jun 1990
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DRUGS; ENCAPSULATION; ELECTROMAGNETIC FIELDS; BIOLOGICAL EFFECTS; LIPOSOMES; CHEMICAL BONDS; PATIENTS; THERAPY; 560400* - Other Environmental Pollutant Effects

Citation Formats

Liburdy, R P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States: N. p., 1993. Web.
Liburdy, R P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States.
Liburdy, R P. Tue . "Electromagnetic field triggered drug and chemical delivery via liposomes". United States.
@article{osti_6245719,
title = {Electromagnetic field triggered drug and chemical delivery via liposomes},
author = {Liburdy, R P},
abstractNote = {The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {3}
}