Electromagnetic field triggered drug and chemical delivery via liposomes
Abstract
The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 6245719
- Patent Number(s):
- 5190761
- Application Number:
- PPN: US 7-537191
- Assignee:
- IMS; EDB-93-123395
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 12 Jun 1990
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DRUGS; ENCAPSULATION; ELECTROMAGNETIC FIELDS; BIOLOGICAL EFFECTS; LIPOSOMES; CHEMICAL BONDS; PATIENTS; THERAPY; 560400* - Other Environmental Pollutant Effects
Citation Formats
Liburdy, R P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States: N. p., 1993.
Web.
Liburdy, R P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States.
Liburdy, R P. Tue .
"Electromagnetic field triggered drug and chemical delivery via liposomes". United States.
@article{osti_6245719,
title = {Electromagnetic field triggered drug and chemical delivery via liposomes},
author = {Liburdy, R P},
abstractNote = {The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {3}
}