Laser particle sorter
Abstract
Method and apparatus are provided for sorting particles, such as biological particles. A first laser is used to define an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam is provided for interrogating the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam is provided to intersect the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis. 2 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 6079226
- Patent Number(s):
- 7126156
- Application Number:
- ON: DE89010956
- Assignee:
- Dept. of Energy
- Patent Classifications (CPCs):
-
G - PHYSICS G02 - OPTICS G02F - DEVICES OR ARRANGEMENTS, THE OPTICAL OPERATION OF WHICH IS MODIFIED BY CHANGING THE OPTICAL PROPERTIES OF THE MEDIUM OF THE DEVICES OR ARRANGEMENTS FOR THE CONTROL OF THE INTENSITY, COLOUR, PHASE, POLARISATION OR DIRECTION OF LIGHT, e.g. SWITCHING, GATING, MODULATING OR DEMODULATING
G - PHYSICS G09 - EDUCATION G09G - ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; LASERS; PARTICLE DISCRIMINATION; DESIGN; INVENTIONS; PARTICLE IDENTIFICATION; SEPARATION EQUIPMENT; 440300* - Miscellaneous Instruments- (-1989); 550000 - Biomedical Sciences, Basic Studies
Citation Formats
Martin, J. C., and Buican, T. N. Laser particle sorter. United States: N. p., 1987.
Web.
Martin, J. C., & Buican, T. N. Laser particle sorter. United States.
Martin, J. C., and Buican, T. N. Mon .
"Laser particle sorter". United States. https://www.osti.gov/servlets/purl/6079226.
@article{osti_6079226,
title = {Laser particle sorter},
author = {Martin, J. C. and Buican, T. N.},
abstractNote = {Method and apparatus are provided for sorting particles, such as biological particles. A first laser is used to define an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam is provided for interrogating the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam is provided to intersect the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis. 2 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Nov 30 00:00:00 EST 1987},
month = {Mon Nov 30 00:00:00 EST 1987}
}