High-pressure liquid chromatographic gradient mixer
Abstract
A gradient mixer effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum band-broadening.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 5708006
- Application Number:
- ON: DE83018103
- Assignee:
- ERA-08-054486; EDB-83-178040
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 42 ENGINEERING; MIXERS; DESIGN; CHROMATOGRAPHY; MICROPROCESSORS; PUMPS; COMPUTERS; ELECTRONIC CIRCUITS; MICROELECTRONIC CIRCUITS; SEPARATION PROCESSES; 420200* - Engineering- Facilities, Equipment, & Techniques
Citation Formats
Daughton, C G, and Sakaji, R H. High-pressure liquid chromatographic gradient mixer. United States: N. p., 1982.
Web.
Daughton, C G, & Sakaji, R H. High-pressure liquid chromatographic gradient mixer. United States.
Daughton, C G, and Sakaji, R H. Wed .
"High-pressure liquid chromatographic gradient mixer". United States.
@article{osti_5708006,
title = {High-pressure liquid chromatographic gradient mixer},
author = {Daughton, C G and Sakaji, R H},
abstractNote = {A gradient mixer effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum band-broadening.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Sep 08 00:00:00 EDT 1982},
month = {Wed Sep 08 00:00:00 EDT 1982}
}
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