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Title: High-pressure liquid chromatographic gradient mixer

Abstract

A gradient mixer effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum band-broadening.

Inventors:
;
Issue Date:
OSTI Identifier:
5708006
Application Number:
ON: DE83018103
Assignee:
ERA-08-054486; EDB-83-178040
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; MIXERS; DESIGN; CHROMATOGRAPHY; MICROPROCESSORS; PUMPS; COMPUTERS; ELECTRONIC CIRCUITS; MICROELECTRONIC CIRCUITS; SEPARATION PROCESSES; 420200* - Engineering- Facilities, Equipment, & Techniques

Citation Formats

Daughton, C.G., and Sakaji, R.H. High-pressure liquid chromatographic gradient mixer. United States: N. p., 1982. Web.
Daughton, C.G., & Sakaji, R.H. High-pressure liquid chromatographic gradient mixer. United States.
Daughton, C.G., and Sakaji, R.H. Wed . "High-pressure liquid chromatographic gradient mixer". United States.
@article{osti_5708006,
title = {High-pressure liquid chromatographic gradient mixer},
author = {Daughton, C.G. and Sakaji, R.H.},
abstractNote = {A gradient mixer effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum band-broadening.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1982},
month = {9}
}