skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ultrashort pulse high repetition rate laser system for biological tissue processing

Abstract

A method and apparatus are disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment. 8 figs.

Inventors:
; ; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States); Office of Naval Research, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
OSTI Identifier:
570385
Patent Number(s):
5720894
Application Number:
PAN: 8-584,522; CNN: Grant N0014-91-C-0134;Grant RR01192
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
FG03-91ER61227
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 24 Feb 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; LASERS; SURGERY; ANIMAL TISSUES; DESIGN; SAMPLE PREPARATION; LASER RADIATION

Citation Formats

Neev, J, Da Silva, L B, Matthews, D L, Glinsky, M E, Stuart, B C, Perry, M D, Feit, M D, and Rubenchik, A M. Ultrashort pulse high repetition rate laser system for biological tissue processing. United States: N. p., 1998. Web.
Neev, J, Da Silva, L B, Matthews, D L, Glinsky, M E, Stuart, B C, Perry, M D, Feit, M D, & Rubenchik, A M. Ultrashort pulse high repetition rate laser system for biological tissue processing. United States.
Neev, J, Da Silva, L B, Matthews, D L, Glinsky, M E, Stuart, B C, Perry, M D, Feit, M D, and Rubenchik, A M. Tue . "Ultrashort pulse high repetition rate laser system for biological tissue processing". United States.
@article{osti_570385,
title = {Ultrashort pulse high repetition rate laser system for biological tissue processing},
author = {Neev, J and Da Silva, L B and Matthews, D L and Glinsky, M E and Stuart, B C and Perry, M D and Feit, M D and Rubenchik, A M},
abstractNote = {A method and apparatus are disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {2}
}

Works referenced in this record:

Nanosecond and femtosecond excimer laser ablation of fused silica
journal, April 1992


Laser-Induced Damage in Dielectrics with Nanosecond to Subpicosecond Pulses
journal, March 1995


Scanning electron microscopy and thermal characteristics of dentin ablated by a short-pulse XeCl excimer laser
journal, January 1993


Time resolved dynamics of subpicosecond laser ablation
journal, June 1993


Femtosecond pulse laser ablation of metallic, semiconducting, ceramic, and biological materials
conference, September 1994


Laser‐induced breakdown by impact ionization in SiO 2 with pulse widths from 7 ns to 150 fs
journal, June 1994


Effect of water content on UV and IR hard tissue ablation
conference, January 1995


Investigation and spectral analysis of the plasma-induced ablation mechanism of dental hydroxyapatite
journal, April 1994


Influence of the laser-spot diameter on photo-ablation rates
journal, January 1995


Ablation of hard dental tissues with an ArF-pulsed excimer laser
conference, June 1991

  • Neev, Joseph; Raney, Daniel; Whalen, William E.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings
  • https://doi.org/10.1117/12.44100

Application of ultrashort laser pulses in dentistry
conference, December 1993


Plasma-mediated ablation of brain tissue with picosecond laser pulses
journal, June 1994


Femtosecond-pulse laser ablation of human corneas
journal, May 1994