Probes labelled with energy transfer coupled dyes

Mathies, R A; Glazer, A; Ju, J

Title: Probes labelled with energy transfer coupled dyes

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Abstract

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids. 7 figs.

Inventors:: Mathies, R A; Glazer, A; Ju, J

Issue Date:: 1997-11-18

Research Org.:: Univ. of California (United States)

Sponsoring Org.:: USDOE, Washington, DC (United States)

OSTI Identifier:: 563688

Patent Number(s):: 5688648

Application Number:: PAN: 8-574,890

Assignee:: Univ. of California, Oakland, CA (United States)

DOE Contract Number:: FG03-91ER61125

Resource Type:: Patent

Resource Relation:: Other Information: PBD: 18 Nov 1997

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA SEQUENCERS; DNA SEQUENCING; DESIGN; FLUORESCENCE; DNA; MOLECULAR BIOLOGY

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                    Mathies, R A, Glazer, A, and Ju, J. Probes labelled with energy transfer coupled dyes.  United States: N. p., 1997. 
        Web.

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                    Mathies, R A, Glazer, A, & Ju, J. Probes labelled with energy transfer coupled dyes.  United States.

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                    Mathies, R A, Glazer, A, and Ju, J. Tue .  
        "Probes labelled with energy transfer coupled dyes".  United States.

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@article{osti_563688,

  title        = {Probes labelled with energy transfer coupled dyes},

  author       = {Mathies, R A and Glazer, A and Ju, J},

  abstractNote = {Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids. 7 figs.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {11}

}

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