Diagnostic method employing MSH2 nucleic acids
Abstract
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +}(RER{sup +}) tumor cells. 19 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Eleanor Roosevelt Institute
- Sponsoring Org.:
- National Insts. of Health, Bethesda, MD (United States); USDOE, Washington, DC (United States)
- OSTI Identifier:
- 563683
- Patent Number(s):
- 5693470
- Application Number:
- PAN: 8-457,175; CNN: Grant CA47527;CA09320;GM26449;CA09243;CA41183;CA42705;CA57435;CA35494
- Assignee:
- Johns Hopkins Univ., Baltimore, MD (United States)
- DOE Contract Number:
- FG02-91ER61139
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 2 Dec 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DIAGNOSTIC TECHNIQUES; GENES; NEOPLASMS; HEREDITARY DISEASES; GASTROINTESTINAL TRACT; MAN; GENE MUTATIONS; DNA SEQUENCING; DNA REPAIR
Citation Formats
Chapelle, A de la, Vogelstein, B, and Kinzler, K W. Diagnostic method employing MSH2 nucleic acids. United States: N. p., 1997.
Web.
Chapelle, A de la, Vogelstein, B, & Kinzler, K W. Diagnostic method employing MSH2 nucleic acids. United States.
Chapelle, A de la, Vogelstein, B, and Kinzler, K W. Tue .
"Diagnostic method employing MSH2 nucleic acids". United States.
@article{osti_563683,
title = {Diagnostic method employing MSH2 nucleic acids},
author = {Chapelle, A de la and Vogelstein, B and Kinzler, K W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +}(RER{sup +}) tumor cells. 19 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 02 00:00:00 EST 1997},
month = {Tue Dec 02 00:00:00 EST 1997}
}
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