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Title: Diagnostic method employing MSH2 nucleic acids

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +}(RER{sup +}) tumor cells. 19 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Eleanor Roosevelt Institute
Sponsoring Org.:
National Insts. of Health, Bethesda, MD (United States); USDOE, Washington, DC (United States)
OSTI Identifier:
563683
Patent Number(s):
5,693,470
Application Number:
PAN: 8-457,175; CNN: Grant CA47527;CA09320;GM26449;CA09243;CA41183;CA42705;CA57435;CA35494
Assignee:
Johns Hopkins Univ., Baltimore, MD (United States) PTO; SCA: 550600; 550900; PA: EDB-98:016275; SN: 98001896331
DOE Contract Number:  
FG02-91ER61139
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 2 Dec 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DIAGNOSTIC TECHNIQUES; GENES; NEOPLASMS; HEREDITARY DISEASES; GASTROINTESTINAL TRACT; MAN; GENE MUTATIONS; DNA SEQUENCING; DNA REPAIR

Citation Formats

Chapelle, A. de la, Vogelstein, B., and Kinzler, K.W. Diagnostic method employing MSH2 nucleic acids. United States: N. p., 1997. Web.
Chapelle, A. de la, Vogelstein, B., & Kinzler, K.W. Diagnostic method employing MSH2 nucleic acids. United States.
Chapelle, A. de la, Vogelstein, B., and Kinzler, K.W. Tue . "Diagnostic method employing MSH2 nucleic acids". United States.
@article{osti_563683,
title = {Diagnostic method employing MSH2 nucleic acids},
author = {Chapelle, A. de la and Vogelstein, B. and Kinzler, K.W.},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +}(RER{sup +}) tumor cells. 19 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {12}
}