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Title: Chemiresistor urea sensor

Abstract

A sensor is disclosed to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects. 16 figs.

Inventors:
Issue Date:
Research Org.:
University of California
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
563679
Patent Number(s):
5,698,083
Application Number:
PAN: 8-517,011
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550600; PA: EDB-98:016274; SN: 98001896312
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 16 Dec 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; UREA; MEASURING INSTRUMENTS; MEASURING METHODS; DIALYSIS; DESIGN; UREASE

Citation Formats

Glass, R.S. Chemiresistor urea sensor. United States: N. p., 1997. Web.
Glass, R.S. Chemiresistor urea sensor. United States.
Glass, R.S. Tue . "Chemiresistor urea sensor". United States.
@article{osti_563679,
title = {Chemiresistor urea sensor},
author = {Glass, R.S.},
abstractNote = {A sensor is disclosed to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance measured. The interdigitated array is fabricated on a suitable substrate. The surface of the array of fingers is covered with a coating containing the enzyme urease which catalyzes the hydrolysis of urea to form the ammonium ion, the bicarbonate ion, and hydroxide-chemical products which provide the basis for the measured signal. In a typical application, the sensor could be used at bedside, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. Also, the chemiresistor used to detect urea, can be utilized with a reference chemiresistor which does not contain urease, and connected in a differential measurement arrangement, such that the reference chemiresistor would cancel out any fluctuations due to background effects. 16 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {12}
}