Osmium-191/iridium-191m radionuclide

Knapp, F F; Butler, T A; Brihaye, C

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Title: Osmium-191/iridium-191m radionuclide

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Abstract

A generator system to provide iridium-191m for clinical imaging applications comprises an activated carbon adsorbent loaded with a compound containing the parent nuclide, osmium-191. The generator, which has a shelf-life in excess of two weeks and does not require a scavenger column, can be eluted with physiologically compatible saline. 4 figs. 3 tabs.

Inventors:: Knapp, Jr, F F; Butler, T A; Brihaye, C

Issue Date:: 1985-08-26

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 5577806

Application Number:: ON: DE86013769

Assignee:: Dept. of Energy

DOE Contract Number:: AC05-84OR21400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; IRIDIUM 191; RADIOISOTOPE GENERATORS; DESIGN; ACTIVATED CARBON; ION EXCHANGE CHROMATOGRAPHY; ISOMERIC NUCLEI; ADSORBENTS; CARBON; CHROMATOGRAPHY; ELEMENTS; HEAVY NUCLEI; IRIDIUM ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SEPARATION PROCESSES; STABLE ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats


                    Knapp, Jr, F F, Butler, T A, and Brihaye, C. Osmium-191/iridium-191m radionuclide.  United States: N. p., 1985. 
        Web.

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                    Knapp, Jr, F F, Butler, T A, & Brihaye, C. Osmium-191/iridium-191m radionuclide.  United States.

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                    Knapp, Jr, F F, Butler, T A, and Brihaye, C. Mon .  
        "Osmium-191/iridium-191m radionuclide".  United States.

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@article{osti_5577806,

  title        = {Osmium-191/iridium-191m radionuclide},

  author       = {Knapp, Jr, F F and Butler, T A and Brihaye, C},

  abstractNote = {A generator system to provide iridium-191m for clinical imaging applications comprises an activated carbon adsorbent loaded with a compound containing the parent nuclide, osmium-191. The generator, which has a shelf-life in excess of two weeks and does not require a scavenger column, can be eluted with physiologically compatible saline. 4 figs. 3 tabs.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1985},

  month        = {8}

}

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Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982

Technical Report Treves, S; Cheng, C

A prototype osmium-191 (T 1/2 = 16 days) ..-->.. iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 ..-->.. Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10/sup -3/% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191more » « less
Development of a new osmium-191-iridium-191m radionuclide generator. Annual report

Technical Report Treves, S; Packard, A B

The major limitation of the Cheng generator design is the chemical instability of the parent trans-dioxotetrachloroosmate(VI) complex. Efforts reported here were directed towards the evaluation of alternative osmium complexes for use as the parent species. Several non-chloro osmium complexes were synthesized that proved to be promising for generator applications and /sup 191/Os-/sup 191m/Ir generators were subsequently developed using these complexes as the parent species. One of these generators (''oxalate'') was found to be particularly promising and has been optimized for potential human use (IND application pending). Although the ''oxalate'' generator provides twice the /sup 191m/Ir yield and less than one-tenthmore » « less
Development of the osmium-191. -->. iridium-191m radionuclide generator. Annual report

Technical Report Treves, S; Packard, A B

The use of /sup 191m/Ir in radionuclide angiography has been the subject of increasing interest in recent years. The /sup 191/Os-/sup 191m/Ir generator that has been used for these studies suffers, however, from low /sup 191m/Ir yield (10%/ml) and higher than desirable /sup 191/Os breakthrough (5 x 10/sup -3/%). We have recently developed a /sup 191m/Ir generator that has higher yield (25 to 30%/ml) and lower breakthrough (<5 x 10/sup -4/%) when eluted with an eluent (0.001 M oxalic acid/0.9% saline) that does not require buffering prior to injection. Studies within the last year have shown the eluate of thismore » « less
Development of a new osmium-191: Iridium-191m radionuclide generator: Final report

Technical Report Treves, S; Packard, A B

The use of iridium-191m (T/sub 1/2/ = 5s) for first-pass radionuclide angiography offers the potential advantages of lower patient radiation dose and the ability to obtain repeated studies without interference from the previously administered radioisotope. These potential advantages have been offset by the absence of satisfactory /sup 191/Os-/sup 191m/Ir generators. The goal of this project was, therefore, the development of an /sup 191/Os-/sup 191m/Ir generator that would be suitable for clinical use. This goal was first sought through modifications of an existing /sup 191/Os-/sup 191m/Ir generator design (i.e., changes in the ion exchange material and eluent) but these changes didmore » « less
Development of the Osmium-191->Iridium-191m radionuclide generator. Annual report

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The use of the ultrashort-lived radionuclide IR-191m (T/sub 1/2/=5s) for radionuclide angiography results in a lower patient radiation dose, higher photon flux, and allows repeated studies that are not possible with the radionuclide currently employed for these studies (Tc-99m, T/sub 1/2/=6h). The Os-191->Ir-191m generator currently being used in clinical studies suffers, however, from low Ir-191m yield (10%), high Os-191 breakthrough (5 x 10/sup -3/%), and an eluent (at pH 1) that must be buffered prior to injection. Initial efforts to improve the performance of this generator met with only limited success. We have, therefore, concentrated on the development of amore » « less

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