skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biomedical silver-109m isotope generator

Abstract

A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m, is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1 x 10-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds. 1 fig.

Inventors:
; ;
Issue Date:
Research Org.:
Los Alamos National Lab., NM (USA)
OSTI Identifier:
5577795
Application Number:
ON: DE86013785
Assignee:
Dept. of Energy TIC; ERA-11-005622; EDB-86-138551
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; RADIOISOTOPE GENERATORS; DESIGN; SILVER 109; CADMIUM 109; ION EXCHANGE CHROMATOGRAPHY; ISOMERIC NUCLEI; PH VALUE; TIN PHOSPHATES; BETA DECAY RADIOISOTOPES; CADMIUM ISOTOPES; CHROMATOGRAPHY; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; OXYGEN COMPOUNDS; PHOSPHATES; PHOSPHORUS COMPOUNDS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SEPARATION PROCESSES; SILVER ISOTOPES; STABLE ISOTOPES; TIN COMPOUNDS; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Wanek, P.M., Steinkruger, F.J., and Moody, D.C. Biomedical silver-109m isotope generator. United States: N. p., 1985. Web.
Wanek, P.M., Steinkruger, F.J., & Moody, D.C. Biomedical silver-109m isotope generator. United States.
Wanek, P.M., Steinkruger, F.J., and Moody, D.C. Tue . "Biomedical silver-109m isotope generator". United States.
@article{osti_5577795,
title = {Biomedical silver-109m isotope generator},
author = {Wanek, P.M. and Steinkruger, F.J. and Moody, D.C.},
abstractNote = {A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m, is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1 x 10-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds. 1 fig.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {3}
}