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Title: No-carrier-added (/sup 18/F)-N-methylspiroperidol

Abstract

The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Lab., Upton, NY (USA)
OSTI Identifier:
5507337
Application Number:
ON: DE86013761
Assignee:
Dept. of Energy
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; DIAGNOSTIC USES; FLUORINE 18; LIGANDS; POSITRON COMPUTED TOMOGRAPHY; TRANQUILIZERS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; NUCLEI; ODD-ODD NUCLEI; PSYCHOTROPIC DRUGS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Shiue, C Y, Fowler, J S, and Wolf, A P. No-carrier-added (/sup 18/F)-N-methylspiroperidol. United States: N. p., 1985. Web.
Shiue, C Y, Fowler, J S, & Wolf, A P. No-carrier-added (/sup 18/F)-N-methylspiroperidol. United States.
Shiue, C Y, Fowler, J S, and Wolf, A P. Fri . "No-carrier-added (/sup 18/F)-N-methylspiroperidol". United States.
@article{osti_5507337,
title = {No-carrier-added (/sup 18/F)-N-methylspiroperidol},
author = {Shiue, C Y and Fowler, J S and Wolf, A P},
abstractNote = {The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {10}
}