No-carrier-added (/sup 18/F)-N-methylspiroperidol
Abstract
The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- OSTI Identifier:
- 5507337
- Application Number:
- ON: DE86013761
- Assignee:
- Dept. of Energy
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; DIAGNOSTIC USES; FLUORINE 18; LIGANDS; POSITRON COMPUTED TOMOGRAPHY; TRANQUILIZERS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; NUCLEI; ODD-ODD NUCLEI; PSYCHOTROPIC DRUGS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Shiue, C Y, Fowler, J S, and Wolf, A P. No-carrier-added (/sup 18/F)-N-methylspiroperidol. United States: N. p., 1985.
Web.
Shiue, C Y, Fowler, J S, & Wolf, A P. No-carrier-added (/sup 18/F)-N-methylspiroperidol. United States.
Shiue, C Y, Fowler, J S, and Wolf, A P. Fri .
"No-carrier-added (/sup 18/F)-N-methylspiroperidol". United States.
@article{osti_5507337,
title = {No-carrier-added (/sup 18/F)-N-methylspiroperidol},
author = {Shiue, C Y and Fowler, J S and Wolf, A P},
abstractNote = {The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Oct 04 00:00:00 EDT 1985},
month = {Fri Oct 04 00:00:00 EDT 1985}
}