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Title: Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]

Abstract

The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free /sup 125/I/sup -/ is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.

Inventors:
; ;
OSTI Identifier:
5503236
Assignee:
TIC; ERA-05-022770; EDB-80-062148
DOE Contract Number:  
W-7505-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; IODINE 125; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; ROSE BENGAL; LABELLING; ETHANOL; ALCOHOLS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMISTRY; DAYS LIVING RADIOISOTOPES; DRUGS; DYES; ELECTRON CAPTURE RADIOISOTOPES; HYDROXY ACIDS; HYDROXY COMPOUNDS; INDICATORS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REAGENTS; SYNTHESIS; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials

Citation Formats

O'Brien, H Jr, Hupf, H B, and Wanek, P M. Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]. United States: N. p., Web.
O'Brien, H Jr, Hupf, H B, & Wanek, P M. Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]. United States.
O'Brien, H Jr, Hupf, H B, and Wanek, P M. . "Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]". United States.
@article{osti_5503236,
title = {Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]},
author = {O'Brien, H Jr and Hupf, H B and Wanek, P M},
abstractNote = {The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free /sup 125/I/sup -/ is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {},
month = {}
}