Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]
Abstract
The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free /sup 125/I/sup -/ is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.
- Inventors:
- OSTI Identifier:
- 5503236
- Assignee:
- TIC; ERA-05-022770; EDB-80-062148
- DOE Contract Number:
- W-7505-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; IODINE 125; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; ROSE BENGAL; LABELLING; ETHANOL; ALCOHOLS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMISTRY; DAYS LIVING RADIOISOTOPES; DRUGS; DYES; ELECTRON CAPTURE RADIOISOTOPES; HYDROXY ACIDS; HYDROXY COMPOUNDS; INDICATORS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REAGENTS; SYNTHESIS; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
Citation Formats
O'Brien, H Jr, Hupf, H B, and Wanek, P M. Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]. United States: N. p.,
Web.
O'Brien, H Jr, Hupf, H B, & Wanek, P M. Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]. United States.
O'Brien, H Jr, Hupf, H B, and Wanek, P M. .
"Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]". United States.
@article{osti_5503236,
title = {Instantaneous radioiodination of rose bengal at room temperature and a cold-kit therefor. [DOE patent application]},
author = {O'Brien, H Jr and Hupf, H B and Wanek, P M},
abstractNote = {The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free /sup 125/I/sup -/ is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {},
month = {}
}
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