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Title: Method for sequencing DNA base pairs

Abstract

The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources, each source being selected to preferentially excite one of the four different bases in the DNA structure. Each particular base being scanned is subjected to such sequence of infrared radiation from the four different sources as that particular base is being scanned. The DNA structure as a whole is separately imaged for each subjection thereof to radiation from one only of each source. 6 figures.

Inventors:
;
Issue Date:
OSTI Identifier:
5349198
Patent Number(s):
5270214
Assignee:
Dept. of Energy, Washington, DC (United States)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Patent File Date: 30 May 1990
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA SEQUENCERS; DNA SEQUENCING; SCANNING ELECTRON MICROSCOPY; INFRARED RADIATION; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; THREE-DIMENSIONAL CALCULATIONS; ELECTROMAGNETIC RADIATION; ELECTRON MICROSCOPY; EQUIPMENT; LABORATORY EQUIPMENT; MICROSCOPY; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATIONS; STRUCTURAL CHEMICAL ANALYSIS; 550200* - Biochemistry; 550400 - Genetics

Citation Formats

Sessler, A M, and Dawson, J. Method for sequencing DNA base pairs. United States: N. p., 1993. Web.
Sessler, A M, & Dawson, J. Method for sequencing DNA base pairs. United States.
Sessler, A M, and Dawson, J. Tue . "Method for sequencing DNA base pairs". United States.
@article{osti_5349198,
title = {Method for sequencing DNA base pairs},
author = {Sessler, A M and Dawson, J},
abstractNote = {The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources, each source being selected to preferentially excite one of the four different bases in the DNA structure. Each particular base being scanned is subjected to such sequence of infrared radiation from the four different sources as that particular base is being scanned. The DNA structure as a whole is separately imaged for each subjection thereof to radiation from one only of each source. 6 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {12}
}