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Title: No-carrier-added (NCA) aryl ([sup 18]F) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings

A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction is The U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.
Inventors:
; ;
Issue Date:
OSTI Identifier:
5302745
Assignee:
Dept. of Energy, Washington, DC (United States) PTO; EDB-94-046447
Patent Number(s):
US 5254726; A
Application Number:
PPN: US 7-711684
Contract Number:
AC02-76CH00016
Resource Relation:
Patent File Date: 7 Jun 1991
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ALDEHYDES; CHEMICAL PREPARATION; FLUORIDES; ELECTRON TRANSFER; FLUORINE 18; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; FLUORINE COMPOUNDS; FLUORINE ISOTOPES; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; SYNTHESIS; 400201* - Chemical & Physicochemical Properties