No-carrier-added (NCA) aryl ([sup 18]F) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings
A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction is The U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.
- Issue Date:
- OSTI Identifier:
- 5302745
- Assignee:
- Dept. of Energy, Washington, DC (United States) PTO; EDB-94-046447
- Patent Number(s):
- US 5254726; A
- Application Number:
- PPN: US 7-711684
- Contract Number:
- AC02-76CH00016
- Resource Relation:
- Patent File Date: 7 Jun 1991
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ALDEHYDES; CHEMICAL PREPARATION; FLUORIDES; ELECTRON TRANSFER; FLUORINE 18; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; FLUORINE COMPOUNDS; FLUORINE ISOTOPES; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; SYNTHESIS; 400201* - Chemical & Physicochemical Properties