Novel polycatecholamide chelating agents

Weitl, F L; Raymond, K N

Title: Novel polycatecholamide chelating agents

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Abstract

Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. Formulas of the compounds are given. To prepare them polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO/sub 3/H, SO/sub 3/M, NO/sub 2/, CO/sub 2/H or CO/sub 2/M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr/sub 3/ or BCl/sub 3/ in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.

Inventors:: Weitl, F L; Raymond, K N

Issue Date:: 1981-08-24

OSTI Identifier:: 5294674

Application Number:: ON: DE82013613

Assignee:: Dept. of Energy

DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACTINIDES; REMOVAL; AMIDES; CHEMICAL PREPARATION; CHELATING AGENTS; AMINES; IN VITRO; IN VIVO; POLYMERS; PYROCATECHOL; SEPARATION PROCESSES; AROMATICS; DEVELOPERS; ELEMENTS; HYDROXY COMPOUNDS; METALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; SYNTHESIS; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 054000 - Nuclear Fuels- Health & Safety; 400301 - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)

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                    Weitl, F L, and Raymond, K N. Novel polycatecholamide chelating agents.  United States: N. p., 1981. 
        Web.

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                    Weitl, F L, & Raymond, K N. Novel polycatecholamide chelating agents.  United States.

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                    Weitl, F L, and Raymond, K N. Mon .  
        "Novel polycatecholamide chelating agents".  United States.

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@article{osti_5294674,

  title        = {Novel polycatecholamide chelating agents},

  author       = {Weitl, F L and Raymond, K N},

  abstractNote = {Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. Formulas of the compounds are given. To prepare them polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO/sub 3/H, SO/sub 3/M, NO/sub 2/, CO/sub 2/H or CO/sub 2/M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr/sub 3/ or BCl/sub 3/ in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1981},

  month        = {8}

}

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