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Title: Isotopic generator for bismuth-212 and lead-212 based on radium

Abstract

Disclosed are method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.

Inventors:
; ;
Issue Date:
Research Org.:
Argonne National Lab., IL (USA)
OSTI Identifier:
5273678
Application Number:
ON: DE85017786
Assignee:
Dept. of Energy EDB-85-148588
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; BISMUTH 212; RADIOISOTOPE GENERATORS; LEAD 212; RADIUM 224; THORIUM 228; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BISMUTH ISOTOPES; DAYS LIVING RADIOISOTOPES; EVEN-EVEN NUCLEI; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; ISOTOPES; LEAD ISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; RADIUM ISOTOPES; THORIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Hines, J.J., Atcher, R.W., and Friedman, A.M. Isotopic generator for bismuth-212 and lead-212 based on radium. United States: N. p., 1985. Web.
Hines, J.J., Atcher, R.W., & Friedman, A.M. Isotopic generator for bismuth-212 and lead-212 based on radium. United States.
Hines, J.J., Atcher, R.W., and Friedman, A.M. Wed . "Isotopic generator for bismuth-212 and lead-212 based on radium". United States.
@article{osti_5273678,
title = {Isotopic generator for bismuth-212 and lead-212 based on radium},
author = {Hines, J.J. and Atcher, R.W. and Friedman, A.M.},
abstractNote = {Disclosed are method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}