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Title: Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]

Abstract

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40/sup 0/C for about 2 hours, and purifying said complex by means of gel chromatography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparitive results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

Inventors:
; ;
Issue Date:
OSTI Identifier:
5176384
Assignee:
Dept. of Energy
DOE Contract Number:  
EY-76-C-02-0016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; RUTHENIUM 103; RUTHENIUM 97; DIAGNOSTIC USES; RADIATION SOURCE IMPLANTS; TRANSFERRIN; LABELLING; BIOLOGICAL LOCALIZATION; CITRIC ACID ESTERS; COMPARATIVE EVALUATIONS; GALLIUM 67; INFLAMMATION; INTERNAL IRRADIATION; LABELLED COMPOUNDS; NEOPLASMS; RADIONUCLIDE KINETICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACID ESTERS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ESTERS; EVEN-ODD NUCLEI; GALLIUM ISOTOPES; GLOBULINS; GLOBULINS-BETA; IMPLANTS; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOTOPES; METALLOPROTEINS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PROTEINS; RADIATION SOURCES; RADIOISOTOPES; RUTHENIUM ISOTOPES; SYMPTOMS; SYNTHESIS; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-); 400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials

Citation Formats

Richards, P, Srivastava, S C, and Meinken, G E. Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]. United States: N. p., 1980. Web.
Richards, P, Srivastava, S C, & Meinken, G E. Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]. United States.
Richards, P, Srivastava, S C, and Meinken, G E. Mon . "Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]". United States.
@article{osti_5176384,
title = {Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]},
author = {Richards, P and Srivastava, S C and Meinken, G E},
abstractNote = {A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40/sup 0/C for about 2 hours, and purifying said complex by means of gel chromatography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparitive results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1980},
month = {11}
}