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Title: Method for synthesizing peptides with saccharide linked enzyme polymer conjugates

A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines. 19 figs.
Inventors:
; ;
Issue Date:
OSTI Identifier:
512426
Assignee:
Cargill, Inc., Minneapolis, MN (United States) PTO; SCA: 550200; PA: EDB-97:113585; SN: 97001827938
Patent Number(s):
US 5,639,633/A/
Application Number:
PAN: 8-466,403
Contract Number:
AC03-76SF00098
Resource Relation:
Other Information: PBD: 17 Jun 1997
Research Org:
University of California
Sponsoring Org:
USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PEPTIDES; CHEMICAL PREPARATION; ENZYMES; COVALENCE; CHEMICAL BONDS