Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Bitensky, M W; Yoshida, Tatsuro

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Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

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Abstract

A method is disclosed using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time is achieved by removing oxygen from the red blood cells at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate. 4 figs.

Inventors:: Bitensky, M W; Yoshida, Tatsuro

Issue Date:: 1997-04-29

Research Org.:: Univ. of California (United States)

OSTI Identifier:: 504949

Patent Number(s):: 5624794

Application Number:: PAN: 8-473,675

Assignee:: Univ. of California, Los Alamos, NM (United States)

DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Resource Relation:: Other Information: PBD: 29 Apr 1997

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; ERYTHROCYTES; STORAGE LIFE; OXYGEN; REMOVAL; TRANSFUSIONS; ATP; CELL MEMBRANES

Citation Formats


                    Bitensky, M W, and Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas.  United States: N. p., 1997. 
        Web.

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                    Bitensky, M W, & Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas.  United States.

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                    Bitensky, M W, and Yoshida, Tatsuro. Tue .  
        "Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas".  United States.

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@article{osti_504949,

  title        = {Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas},

  author       = {Bitensky, M W and Yoshida, Tatsuro},

  abstractNote = {A method is disclosed using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time is achieved by removing oxygen from the red blood cells at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate. 4 figs.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {4}

}

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Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

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Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.
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