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Title: Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging

Abstract

Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings

Inventors:
; ;
Issue Date:
OSTI Identifier:
5043183
Patent Number(s):
5292938
Application Number:
PPN: US 7-867533
Assignee:
Associated Universities, Inc., Washington, DC (United States)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Patent File Date: 13 Apr 1992
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHELATING AGENTS; CHEMICAL PREPARATION; EMISSION COMPUTED TOMOGRAPHY; RADIOIMMUNOASSAY; RADIOIMMUNOTHERAPY; RADIOPHARMACEUTICALS; BIOASSAY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; IMMUNOASSAY; IMMUNOTHERAPY; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; RADIOASSAY; RADIOIMMUNODETECTION; RADIOLOGY; RADIOTHERAPY; SYNTHESIS; THERAPY; TOMOGRAPHY; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Mease, R C, Mausner, L F, and Srivastava, S C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging. United States: N. p., 1994. Web.
Mease, R C, Mausner, L F, & Srivastava, S C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging. United States.
Mease, R C, Mausner, L F, and Srivastava, S C. Tue . "Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging". United States.
@article{osti_5043183,
title = {Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging},
author = {Mease, R C and Mausner, L F and Srivastava, S C},
abstractNote = {Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {3}
}