Acridine-intercalator based hypoxia selective cytotoxins
Abstract
Hypoxia selective cytotoxins of the general formula STR1 wherein n is from 1 to 5, and NO[sub 2] is in at least one of the 2, 4 or 5-positions of the imidazole are developed. Such compounds have utility as radiosensitizers and chemosensitizers. 9 figs.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 5026223
- Patent Number(s):
- 5294715
- Application Number:
- PPN: US 7-649703
- Assignee:
- Univ. of Pittsburgh, Pittsburgh, PA (United States)
- DOE Contract Number:
- FG02-89ER60869
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 1 Feb 1991
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIMITOTIC DRUGS; CHEMICAL PREPARATION; ACRIDINES; ANOXIA; RADIOSENSITIVITY EFFECTS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; AROMATICS; AZAARENES; AZINES; DRUGS; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; SYNTHESIS; 560300* - Chemicals Metabolism & Toxicology; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
Citation Formats
Papadopoulou-Rosenzweig, M, and Bloomer, W D. Acridine-intercalator based hypoxia selective cytotoxins. United States: N. p., 1994.
Web.
Papadopoulou-Rosenzweig, M, & Bloomer, W D. Acridine-intercalator based hypoxia selective cytotoxins. United States.
Papadopoulou-Rosenzweig, M, and Bloomer, W D. Tue .
"Acridine-intercalator based hypoxia selective cytotoxins". United States.
@article{osti_5026223,
title = {Acridine-intercalator based hypoxia selective cytotoxins},
author = {Papadopoulou-Rosenzweig, M and Bloomer, W D},
abstractNote = {Hypoxia selective cytotoxins of the general formula STR1 wherein n is from 1 to 5, and NO[sub 2] is in at least one of the 2, 4 or 5-positions of the imidazole are developed. Such compounds have utility as radiosensitizers and chemosensitizers. 9 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 15 00:00:00 EST 1994},
month = {Tue Mar 15 00:00:00 EST 1994}
}
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